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Answer:
It all depends on your strategy and what you're comfortable with. Some traders set up multiple lots to enable them to exit (or enter) the market at multiple points (different profit targets). This enables them to gather more pips if the trade goes their way. Some move their stop loss to their entry price once their first profit target is hit to ensure a "risk free trade." Of course, there is always a downside. If price, say, hits your first profit target but suddenly reverses and hits the stop loss of your second position, you end up not getting as much profit as you would if you had only one lot. As you can see, it's all up to you and what your strategy is!
